Urinary excretion of gluten immunoreactive peptides as an indicator of gastrointestinal function after fasting and dietary provocation in healthy volunteers

HIGHLIGHTS

• What: The authors investigated the kinetic and dynamic patterns of u-GIP excretion after simultaneous consumption of gluten, lactulose, and mannitol to explore pathways of epithelial barrier translocation and preliminarily assess its potential as a standard food antigen probe in intestinal permeability analysis. The authors evaluated the excretion dynamics of lactulose and mannitol, widely used probes for assessing intestinal permeability, in urine samples collected from healthy volunteers who consumed controlled doses under regulated dietary conditions. The study provides novel insights into the temporal patterns of u-GIP excretion following gluten ingestion under fasting conditions.
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