HIGHLIGHTS
- who: STING et al. from the Northwest University, China have published the paper: Urolithin A Attenuates Hyperuricemic Nephropathy in Fructose-Fed Mice by Impairing STING-NLRP3 Axis-Mediated In fl ammatory Response via Restoration of Parkin-Dependent Mitophagy, in the Journal: (JOURNAL)
- what: In this study, the therapeutic effect of UroA was investigated in a fructose-induced hyperuricemic nephropathy mouse model.
- how: Similarly the data showed that the inhibitory effect of UroA in STINGNLRP3 activation was impaired after silencing Parkin in HK-2 cells indicating that UroA may abolish STING-NLRP3 axismediated inflammation . . .
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