Use of ordered beta regression unveils cognitive flexibility index and longitudinal cognitive training signatures in normal and alzheimer’s disease pathological aging

HIGHLIGHTS

• What: The aim of this study is to explore whether the application of GLMMs to a multi-strategy approach can identify differences by sex, genotype, or age in a group of normal (gold standard wild-type C57BL/6strain) and AD-pathologically aged mice (3xTg-AD mice) that may have been overlooked in traditional variable analysis. The authors propose a measurement of cognitive flexibility, which was calculated as the percentage of time spent until the first strategy used to find the platform changed. In the analysis , quantitative variables gained significance primarily during the CUE stage, where the animals . . .
  

   

  

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