Use of sulfated linked cyclitols as heparan sulfate mimetics to probe the heparin/heparan sulfate binding specificity of proteins*

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  • who: Craig Freeman from the (UNIVERSITY) have published the research work: Use of Sulfated Linked Cyclitols as Heparan Sulfate Mimetics to Probe the Heparin/Heparan Sulfate Binding Specificity of Proteins*, in the Journal: (JOURNAL) of September/20,/2004
  • what: This study compares the ability of 15 different sulfated linked cyclitols to interact with 10 functionally diverse proteins. The functional relevance of this phenomenon may be that it prevents HS fragments released from the ECM at sites of inflammation and tissue repair from totally displacing LpL from the matrix or totally inactivating ECM-degrading enzymes such . . .

     

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