Using coding and non-coding rare variants to target candidate genes in patients with severe tinnitus

HIGHLIGHTS

SUMMARY

    Published in partnership with CEGMR, King Abdulaziz University Clinical features in Swedish patients with tinnitus for all (TIGER) and severe tinnitus (SEVTIN) cohorts. When the authors compared genes with variants significantly enriched in both TIGER and SEVTIN, a total of 17 genes were shared between both cohorts (Supplementary Table 4). To search for associations of rare variants in the same gene, the authors retrieved the individuals reporting at least two variants in the same gene showing enrichment of LoF SNVs (Fig 1a and Supplementary Table 4). The authors also found some rare variants previously . . .

     

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