Using cryo-em to understand antimycobacterial resistance in the catalase-peroxidase (katg) from mycobacterium tuberculosis

HIGHLIGHTS

• who: Asma Munir from the University of Cambridge, Cambridge, GA, UK have published the Article: Using cryo-EM to understand antimycobacterial resistance in the catalase-peroxidase (KatG) from Mycobacterium tuberculosis, in the Journal: (JOURNAL)
• what: The authors report the cryo-EM structures of WT KatG from M. tuberculosis with and without INH bound at 2.7 and 3.7 Å resolution, respectively, and have identified an ensemble of potential INH binding_sites. Superposition of the cryo-EM models with and without INH showed no significant structural deviations and, thus, based on the higher resolution of KatG . . .
  

   

  

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