Using quantitative single molecule localization microscopy to optimize multivalent her2-targeting ligands

HIGHLIGHTS

• who: Devin L. Wakefield from the TissueGnostics GmbH, Austria Yale University, United States have published the research: Using quantitative single molecule localization microscopy to optimize multivalent HER2-targeting ligands, in the Journal: (JOURNAL) of 17/04/2023
• what: Based on the analysis and lower frequencies of HER2 monomers were observed when TmemAb-AF647 was combined with multivalent meditopes. The authors show that mAb(s)/memAb-ligand treatments affect cell surface receptor clustering; the observed effects were dependent on ligand valency. The authors show that changes to HER2 organization at early time points are accompanied by . . .
  

   

  

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