Using the hepatitis c virus rna-dependent rna polymerase as a model to understand viral polymerase structure, function and dynamics

HIGHLIGHTS

  • who: Ester Sesmero and Ian F. Thorpe from the Department of Chemistry and Biochemistry, University of Maryland Baltimore County have published the research work: Using the Hepatitis C Virus RNA-Dependent RNA Polymerase as a Model to Understand Viral Polymerase Structure, Function and Dynamics, in the Journal: Viruses 2015, 7, 3974-3994 of 17/07/2015
  • what: The authors focus on NNIs in this review because the role of NIs as terminators of RNA synthesis is well understood.

SUMMARY

    The palm domain is the most highly conserved domain across different polymerases . . .

     

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