HIGHLIGHTS
- who: Alexandrina Pancheva and colleagues from the Institute for Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom have published the paper: Using topic modeling to detect cellular crosstalk in scRNA-seq, in the Journal: (JOURNAL)
- what: The authors propose a novel method based on LDA that captures changes in gene expression as a result of interaction. The authors show how the proposed model behaves when fit on synthetic doublets with some upregulated genes. The authors demonstrate the challenges of applying the method to a 10x Chromium dataset bronchoalveolar lavage fluid (BALF) of patients . . .
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