HIGHLIGHTS
- who: Zhuhua Wu from the (UNIVERSITY) have published the article: USP15 promotes pulmonary vascular remodeling in pulmonary hypertension in a YAP1/TAZ-dependent manner, in the Journal: (JOURNAL) of 12/01/2023
- what: More surprisingly, YAP1/TAZ signaling was evidently activated in PASMCs from experimental PH20, and YAP1 interference prominently suppressed the proliferation of vascular smooth muscle cells in_vitro21,22, suggesting the contribution of YAP1 to PASMC proliferation during PH GEO database Microarray data from the GEO database (GSE113439, GSE15197, and GSE53408) were used to identify aberrantly expressed USP15 in the lungs of PAH patients . . .
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