Usp39 stabilizes β-catenin by deubiquitination and suppressing e3 ligase trim26 pre-mrna maturation to promote hcc progression

HIGHLIGHTS

  • who: Weiwei Wang from the In vivo experiments The nude mouse xenograft model:, week-old male nude mice (18, g) were purchased from the National Model Animal Center of Nanjing University and maintained in a specific pathogen-free environment with free access to food and water and a, h light/dark cycleThe mice were randomly divided into a control group (n=6), sh, group (n=6) and shTRIM26+shb-catenin group (n=6). SK-hep, cells (, u00d7, ) stably transduced with sh, and shTRIM26+shu03b2-catenin were injected subcutaneously into the flanks of, week-old male BALB/c . . .

     

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