Usp48 restrains resection by site-specific cleavage of the brca1 ubiquitin mark from h2a

HIGHLIGHTS

• who: Michael Uckelmann from the Centre, Plesmanlaan, CX Amsterdam, The NetherlandsUniversity of have published the research work: USP48 restrains resection by site-specific cleavage of the BRCA1 ubiquitin mark from H2A, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: The authors show that in cells USP48 counteracts BRCA1 E3 ligase activity, restricting DNA end resection and RAD51 recruitment. The authors provide evidence that USP48 acts to prevent extensive resection and restrict the use of SSA. To quantify the activity the authors analyzed cleavage time courses of H2ABRCA1ub, H2A168ub, or H2APRC1ub on gel using fluorescence of . . .
  

   

  

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