Usp7 inactivation suppresses apc-mutant intestinal hyperproliferation and tumor development

HIGHLIGHTS

• who: Laura Novellasdemunt from the Francis Crick Institute, Midland Road, London , AT, UK have published the research: USP7 inactivation suppresses APC-mutant intestinal hyperproliferation andu00a0tumor development, in the Journal: (JOURNAL) of February/14,/2023
• what: The authors show in vivo that deletion of Usp7 in Apc-truncated mice inhibits crypt hyperproliferation and intestinal tumor development. It should be noted that this study focuses mainly on the intesti- nal tract.
• how: To determine if gut inflammation mediated by USP7 deficiency in Apchet mice is early or late onset the authors collected intestinal tissues 15 . . .
  

   

  

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