Utility of in silico-identified-peptides in spike-s1 domain and nucleocapsid of sars-cov-2 for antibody detection in covid-19 patients and antibody production

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SUMMARY

    The S protein is highly antigenic; however, some peptides were shorter than eight amino_acids, and during the second round of selection, they were eliminated: eleven in S1 NTD, five in S1 RBD and twenty-six in S2. The authors selected seven peptides in the S1 domain, two in the S1 NTD from amino_acids 13 to 20 (RTQLPPAYTNS) and 153 to 165 (MESEFRVYSSANN), while the selected peptides in the S1 RBD were located from amino_acids 438 to 537. Unlike the S protein, most of the peptides in the N protein were found internally, and only . . .

     

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