Utilization of aminoguanidine prevents cytotoxic effects of semen

HIGHLIGHTS

  • who: Mirja Harms and collaborators from the Institute of Molecular Virology, University Ulm Medical Center, Ulm, Germany have published the paper: Utilization of Aminoguanidine Prevents Cytotoxic Effects of Semen, in the Journal: (JOURNAL) of 30/06/2022
  • what: The authors show that in the presence of fetal calf serum seminal plasma as well as the polyamines spermine and spermidine are highly cytotoxic to immortalized cells primary blood mononuclear cells and vaginal tissue. This experiment showed that AG concentrations of 50, 500, and oxidases in FCS are responsible for generating toxic polyamine products, as previously 5000 . . .

     

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