Utilization of physiologically based pharmacokinetic modeling in pharmacokinetic study of natural medicine: an overview

HIGHLIGHTS

  • who: Qiuyu Jia and collaborators from the Department of Clinical Pharmacy and Pharmacy Administration, School of Pharmacy, Fudan University, Shanghai, China have published the Article: Utilization of Physiologically Based Pharmacokinetic Modeling in Pharmacokinetic Study of Natural Medicine: An Overview, in the Journal: Molecules 2022, 8670 of 29/09/2022
  • what: This study showed that STA had a more significant inhibitory effect on cyclophosphamide metabolism than SIA, and cyclophosphamide`s adverse drug reactions and toxicity should be closely monitored.
  • how: The model also considered the impact of the CYP2B6 polymorphism in DDIs between efavirenz . . .

     

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