HIGHLIGHTS
- who: Hezi Hayun from the the National Institute Gurion University have published the research work: Utilizing genetic code expansion to modify N-TIMP2 specificity towards MMP-2, MMP-9, and MMP-14, in the Journal: Scientific Reports Scientific Reports
- how: To investigate the structural basis for the selectivity enhancements of N-TIMP2-S69HqAla and N-TIMP2-S69DOPA variants toward MMP-2 and MMP-9 in preference to MMP-14 the authors used molecular modeling approaches.
SUMMARY
In an attempt to enhance the specificity of N-TIMP2, the authors chose a strategy . . .
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