HIGHLIGHTS
- who: Top from the Department Pharmacy, Pharmaceutical Biology, Ludwig-Maximilians-University Munich, Munich, Germany have published the article: V-ATPase inhibition increases cancer cell stiffness and blocks, in the Journal: (JOURNAL)
- what: The authors report a novel therapeutic potential V-ATPase inhibition in HCC by altering the mechanical phenotype cancer cells leading to reduced proliferative signaling. This study provides evidence that interfering with cholesterol metabolism by V-ATPase inhibition leads to an increased stiffness of tumor cells and affects membranerelated Ras signaling known to often be aberrant in malignant cells . Until recently, the main aim . . .
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