HIGHLIGHTS
- who: John Nickerson from the Departments of Biomedical Engineering and Ophthalmology, Duke University, Durham, NC Purpose: One of the current limitations in developing novel glaucoma drugs that target the trabecular meshwork (TM) is the induced corneal toxicity from eyedrop formulationsTo avoid the corneal toxicity, an alternative approach would be to deliver TM drugs through the sclera. To this end, we quantified ex vivo diffusion coefficient of a potential TM drug, ethacrynic acid (ECA), and investigated mechanisms of ECA transport in the sclera. Methods: An Ussing-type diffusion apparatus was built to measure the apparent diffusion coefficient of . . .
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