Variation in the serpina6/serpina1 locus alters morning plasma cortisol, hepatic corticosteroid binding globulin expression, gene expression in peripheral tissues, and risk of cardiovascular disease

HIGHLIGHTS

• who: Andrew A. Crawford from the (UNIVERSITY) have published the article: Variation in the SERPINA6/SERPINA1 locus alters morning plasma cortisol, hepatic corticosteroid binding globulin expression, gene expression in peripheral tissues, and risk of cardiovascular disease, in the Journal: (JOURNAL)
• what: The authors aimed: to identify additional specific loci influencing cortisol; to refine where in the SERPINA6/A1 locus there is an influence on cortisol; to establish whether SERPINA6/A1 variation influences tissue-specific expression of CBG and α1-antitrypsin; and to confirm whether high cortisol is causal in ischaemic heart disease and test if . . .
  

   

  

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