HIGHLIGHTS
SUMMARY
The main reasons for this mismatch stem from the impossibility of recapitulating, either in cells or through specific algorithms, the complex and only partially known interplay resulting from exposure to the final destination (accumulation, transformations-such as protein corona-clearance, and toxicity) of the NPs in multicellular organisms. Similarly, changes in the surface and the shape of gold NPs strongly influenced the biodistribution but led to a minimal effect on the overall blood count and an almost complete absence of modifications in basal hematochemistry (creatinine, bilirubin, transaminases and uric acid). The route of exposure . . .
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