HIGHLIGHTS
- who: Cho Yeow Koh from the (UNIVERSITY) have published the paper: Variegin, a Novel Fast and Tight Binding Thrombin Inhibitor from the Tropical Bont Tick*, in the Journal: (JOURNAL)
- how: The results indicated that AP18 binds to exosite-I and slightly enhanced thrombin amidolytic activity comparable to the reported behavior of hirudin C terminus suggesting similar roles for these two sequences.
SUMMARY
Some examples of direct thrombin inhibitors include hirudin, hirulog (or bivalirudin), and agratroban. This C-terminal tail interacts with thrombin exosite-I through electrostatic and hydrophobic_interactions. The N-terminal . . .
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