Vascular defects associated with hereditary hemorrhagic telangiectasia revealed in patient-derived isogenic ipscs in 3d vessels on chip

HIGHLIGHTS

  • who: Valeria V. Orlova from the Leiden University Medical Center, Leiden ZA, the Netherlands have published the Article: Vascular defects associated with hereditary hemorrhagic telangiectasia revealed in patient-derived isogenic iPSCs in 3D vessels on chip, in the Journal: (JOURNAL) of July/12,/2022
  • what: The authors aimed to establish an efficient and scalable system that would recapitulate the formation of defective blood vessels in patients with HHT, based on patient-derived human induced pluripotent stem_cells (HHT1-hiPSCs).
  • how: The results showed that although VEC junctional distribution was comparable junctional distribution of ZO1 . . .

     

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