HIGHLIGHTS
- who: François-Xavier Boittin from the (UNIVERSITY) have published the research work: Vasodilation by the Calcium-mobilizing Messenger Cyclic ADP-ribose*, in the Journal: (JOURNAL) of May/17,/2002
- what: The authors show here that cyclic adenosine_diphosphate-ribose (cADPR), by activating RyRs, mediates, in part, hyperpolarization and vasodilation by -adrenoceptors. The authors show here that hyperpolarization and dilation by adenylyl cyclase-coupled receptors is mediated, in part, by cADPR-dependent SR Ca2⫹ release and consequent activation of BKCa channels in pulmonary artery smooth muscle. no-cADPR; RyR, ryanodine receptors; PGF2␣, (5Z, 9␣, 11␣, 13E . . .
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