HIGHLIGHTS
- who: Hyun Gwan Park and colleagues from the Rockefeller University Press JCell Biol. , Vol. , No. , e, have published the research: Vav independently regulates synaptic growth and plasticity through distinct actin-based processes, in the Journal: (JOURNAL) of 20/03/2023
- what: The authors show that the Rho-type GEF Vav acts upstream of Rac1 to inhibit synaptic growth through macropinocytosis. The authors propose that actin-regulatory Vav-Rac1-SCAR signaling independently regulates structural and functional presynaptic plasticity by driving macropinocytosis and RP mobilization, respectively.............................................................................................................................................................................. The authors provide the first evidence for Vav`s presynaptic role . . .
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