HIGHLIGHTS
- who: Jiang Zhu from the Washington University School of Medicine, St Louis, MO, USA have published the research: VCP suppresses proteopathic seeding in neurons, in the Journal: (JOURNAL)
- what: The authors propose that VCP's surveillance of permeabilized endosomes may protect against the spread of pathogenic protein aggregates.
- how: The authors analyzed in vivo activity by immunostaining for phosphorylated αS following intrastriatal injection of αS seeds in control or disease mutation carrying mice. The authors utilized an αS seeding FRET biosensor to screen a CRISPR knockout library. This approach identified multiple suppressors of . . .
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