Vcp suppresses proteopathic seeding in neurons

HIGHLIGHTS

• who: Jiang Zhu from the Washington University School of Medicine, St Louis, MO, USA have published the article: VCP suppresses proteopathic seeding in neurons, in the Journal: (JOURNAL)
• what: The authors propose that VCP`s surveillance of permeabilized endosomes may protect against the spread of pathogenic protein aggregates.
• how: The authors analyzed in vivo activity by immunostaining for phosphorylated u03b1S following intrastriatal injection of u03b1S seeds in control or disease mutation carrying mice. The authors utilized an u03b1S seeding FRET biosensor to screen a CRISPR knockout library. This approach identified multiple suppressors of . . .
  

   

  

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