Verapamil inhibits kir2.3 channels by binding to the pore and interfering with pip

HIGHLIGHTS

• who: Panagiotis Xynogalos from the Department of Cardiology, Medical University Hospital Heidelberg, Im Neuenheimer Feld, Heidelberg, Germany have published the paper: Verapamil inhibits Kir2.3 channels by binding to the pore and interfering with PIP, in the Journal: (JOURNAL)
• what: The authors provide experimental data to delineate the molecular basis of the effect of verapamil on Kir2.3. The authors demonstrate that verapamil also blocks Kir2.2 and Kir2.3 channels in a heterologous expression system. By generating channel mutants in putative binding_sites already described, the authors demonstrate dependence of block on sites E291 and . . .
  

   

  

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