HIGHLIGHTS
- who: Alexandra-Larisa Condurat from the Institut University of have published the research work: Verteporfin-induced proteotoxicity impairs cell homeostasis and survival in neuroblastoma subtypes independent of YAP/TAZ expression, in the Journal: Scientific Reports Scientific Reports
- what: The authors aimed to investigate whether YAP/TAZ expression is required for VPF-induced NB cell death. This study showed that VPF efficiently impairs NB cell viability via the formation of HMW proteotoxic complexes in both MYCN-NA/predominantly YAP-positive NB lines, as well as in MYCN-A/predominantly YAP-negative NB models, independent of YAP . . .
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