Vesicular stomatitis virus replicon expressing the vp2 outer capsid protein of bluetongue virus serotype 8 induces complete protection of sheep against challenge infection

HIGHLIGHTS

• who: Stefanie Kochinger and colleagues from the Currently, there is no universal vaccine available that would protect against all , known serotypes of BTVThe VRP technology is not restricted to , antigens but may be used to express , antigen of other BTV serotypes as well. Thus, in case a new serotype emerges in a non-endemic region, a recombinant VRP vaccine matching this serotype could be rapidly produced and used for emergency vaccination. This should be particularly valuable for BTV strains for which inactivated vaccines are not readily available because the corresponding viruses do not propagate well in cell . . .
  

   

  

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