Vhl-recruiting protac attenuates renal fibrosis and preserves renal function via simultaneous degradation of smad3 and stabilization of hif-2α

HIGHLIGHTS

• who: Jiayi Yang from the Department of Nephrology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China have published the paper: VHL-recruiting PROTAC attenuates renal fibrosis and preserves renal function via simultaneous degradation of Smad3 and stabilization of HIF-2u03b1, in the Journal: (JOURNAL)
• what: Hepcidin, a strong negative regulator of iron metabolism, was considered as the main reason of iron utilization disorder in renal anemia. Since Smad3 is ubiquitously expressed and the study has been mainly focused on renal interstitium, the evaluation of Smad3 and HIF-2u03b1 protein levels with PROTAC treatment . . .
  

   

  

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