HIGHLIGHTS
- who: Miaoge Xue from the College State University of Chicago, Chicago, IL, USA have published the research: Viral N6-methyladenosine upregulates replication and pathogenesis of human respiratory syncytial virus, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
- what: The authors provide evidence that m6A could be a target for the development of live attenuated vaccine candidates. The authors showed that overexpression of both m6A reader and writer proteins positively regulated RSV replication while knockdown inhibited RSV gene_expression and replication. The authors designed mutations in predicted m6A sites to avoid as much as possible alterations to the . . .
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