Viral vectors expressing group b meningococcal outer membrane proteins induce strong antibody responses but fail to induce functional bactericidal activity

HIGHLIGHTS

  • who: Leanne Marsay from the Oxford, Department of Paediatrics, University of Oxford and the NIHR Oxford Biomedical Research Centre, CCVTM, Churchill Lane, Oxford , LE, United Kingdom have published the article: Viral vectors expressing group B meningococcal outer membrane proteins induce strong antibody responses but fail to induce functional bactericidal activity, in the Journal: (JOURNAL)
  • what: This study investigated the suitability of adenoviruses encoding bacterial surface proteins to induce antibody responses to N. meningitidis PorA and FetA. activator (tPA) leader fused and non-tPA leader fused (cytosolic) were generated to assess immunogenicity when delivered by adenoviral_vectors . . .

     

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