HIGHLIGHTS
- who: Jienyu Ding from the (UNIVERSITY) have published the paper: Visualizing RNA conformational and architectural heterogeneity in solution, in the Journal: (JOURNAL) of 30/03/2022
- what: Through direct visualization using atomic force microscopy (AFM) and the adenosylcobalamin riboswitch aptamer domain as an example, the authors show that a single RNA sequence folds into conformationally and architecturally heterogeneous structures under near-physiological solution conditions.
- how: For this study the authors selected the protocol which produces the sample with the highest population of bindingcompetent conformers based on the ITC data and AFM images as . . .
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