Visualizing the domino-like prepore-to-pore transition of streptolysin o by high-speed afm

HIGHLIGHTS

• who: Hirotaka Ariyama from the 20u20111192, Japan have published the research work: Visualizing the Domino-Like Prepore-to-Pore Transition of Streptolysin O by High-Speed AFM, in the Journal: (JOURNAL)
• future: This study highlights future research avenues in which further investigations into structural changes of the TMH regions and the TMH-D1/2 interface are required to elucidate the prepore-to-pore transition mechanism in greater detail. Future work will require experimental evaluation of the energy barrier using biochemical and biophysical methods with mutants that can be used to quantify the degree of stabilization . . .
  

   

  

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