HIGHLIGHTS
- who: Faustine Henot from the (UNIVERSITY) have published the research: Visualizing the transiently populated closed-state of human HSP90 ATP binding domain, in the Journal: (JOURNAL) of 28/03/2022
- what: The authors demonstrate that in solution the HSP90u03b1 ATP binding domain transiently samples a functionally relevant ATP-lid closed state, distant by more than 30 u00c5 from the ground_state. The authors have demonstrated that the ATP-lid segment of human HSP90u03b1-NTD samples two distant conformations in solution.
- how: For R46A mutant as NOEs that are specific to the ATP-lid open . . .
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