Vitamin b3-based biologically active compounds as inhibitors of human cholinesterases

HIGHLIGHTS

  • who: Antonio Zandona et al. from the Institute for Medical Research and Occupational Health, Ksaverska c2, Zagreb, CroatiaInstitute of Pathophysiology, Faculty of Medicine, University of Ljubljana, Zaloska, Ljubljana have published the article: Vitamin B3-Based Biologically Active Compounds as Inhibitors of Human Cholinesterases, in the Journal: (JOURNAL)
  • what: The tested vitamin B3-derivatives reversibly inhibited both cholinesterases in the micromolar range and the effect was dependent on the substituent present on the side ring of the molecule.
  • how: This result is consistent with previous studies which showed that some nicotinamide derivatives are inhibitors . . .

     

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