Vitamin d analogs bearing c-20 modifications stabilize the agonistic conformation of non-responsive vitamin d receptor variants

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• who: Anna Y. Belorusova et al. from the Institut de Gu00e9nu00e9tique et de Biologie Molu00e9culaire et Cellulaire (IGBMC), Illkirch, France have published the research work: Vitamin D Analogs Bearing C-20 Modifications Stabilize the Agonistic Conformation of Non-Responsive Vitamin D Receptor Variants, in the Journal: (JOURNAL)
• what: The authors show that both VDR ligands restore the transcriptional activities of VDR unresponsive to the natural ligand and identified in patients with rickets. The authors show these modifications Glu319Val, His305Gln, Trp286Arg, Leu227Pro, Ile268Thr, and Ile314Ser). restore the activity of the 1,25D3-unresponsive VDR variants that . . .
  

   

  

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