Vitamin d analogs bearing c-20 modifications stabilize the agonistic conformation of non-responsive vitamin d receptor variants

HIGHLIGHTS

• who: Anna Y. Belorusova et al. from the Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Illkirch, France have published the Article: Vitamin D Analogs Bearing C-20 Modifications Stabilize the Agonistic Conformation of Non-Responsive Vitamin D Receptor Variants, in the Journal: (JOURNAL)
• what: The authors show that both VDR ligands restore the transcriptional activities of VDR unresponsive to the natural ligand and identified in patients with rickets. The authors show these modifications Glu319Val, His305Gln, Trp286Arg, Leu227Pro, Ile268Thr, and Ile314Ser). restore the activity of the 1,25D3-unresponsive VDR . . .
  

   

  

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