Volume-associated clinical and histopathological effects of intranasal instillation in syrian hamsters: considerations for infection and therapeutic studies

HIGHLIGHTS

• who: Catalina Forero and colleagues from the Atlanta, GA, USA have published the research: Volume-Associated Clinical and Histopathological Effects of Intranasal Instillation in Syrian Hamsters: Considerations for Infection and Therapeutic Studies, in the Journal: Pathogens 2022, 898 of /2022/
• what: The authors investigate four intranasal (IN) instillation volumes in hamsters (50 100 200 or 400 µL). The authors explore the volumetric-associated effects of IN instillation in Syrian hamsters on clinical presentation, oxygen saturation, CBC, radiology, and histopathology, using Dulbecco's modified Eagle's medium (DMEM), a common diluent for virus stocks.
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