Vorinostat improves myotonic dystrophy type 1 splicing abnormalities in dm1 muscle cell lines and skeletal muscle from a dm1 mouse model

HIGHLIGHTS

• who: Nafisa Neault and colleagues from the Children`s Hospital of Eastern Ontario Research Institute, Ottawa, ON K H , Canada Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa have published the research work: Vorinostat Improves Myotonic Dystrophy Type 1 Splicing Abnormalities in DM1 Muscle Cell Lines and Skeletal Muscle from a DM1 Mouse Model, in the Journal: (JOURNAL)
• how: To further explore the role of HDAC inhibition in the observed effects two additional pan-HDAC inhibitors belinostat and TSA were tested in_vitro. In this study DMSO was used at a concentration . . .
  

   

  

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