Vrk1 as a synthetic lethal target in vrk2-methylated cancers of the nervous system

HIGHLIGHTS

• who: M. Moyer et al. from the Jonathan So1, *, Nathaniel WMabe2, *, Bernhard Englinger2, , *, Kin-Hoe Chow5, SydneyMedical University have published the paper: VRK1 as a synthetic lethal target in VRK2-methylated cancers of the nervous system, in the Journal: (JOURNAL)
• what: To verify the synthetic lethal relationship between VRK1 and VRK2 experimentally, the authors focused on a panel of 4 GBM cell lines with heterogeneous expression of VRK2 (Supplementary Fig S6A, B).
• how: For tamoxifen inducible sgRNA expression the authors utilized the CRISPR-Switch system as described by Chylinski et_al(17).
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