Wasp family verprolin-homologous protein-2 (wave2) and wiskott-aldrich syndrome protein (wasp) engage in distinct downstream signaling interactions at the t cell antigen receptor site*

HIGHLIGHTS

• who: Maor H. Pauker from the Maor HPauker1, Barak Reicher1, Noah Joseph, Inbal Wortzel, Shlomi Jakubowicz, Elad Noy, Orly Perl, and Mira Barda-Saad, From the Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel Background: The regulatory mechanisms and potential redundancy of the structurally related actin nucleation promoting factors, and WASp, are poorly understood. Results: Following T cell activation, and WASp are recruited to the TCR site and then dissociate. Conclusions: , and WASp share similar recruitment mechanisms but differ in their subsequent molecular interactions and dynamics. Significance: These differences may explain . . .
  

   

  

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