Wentilactone a as a novel potential antitumor agent induces apoptosis and g2/m arrest of human lung carcinoma cells, and is mediated by hras-gtp accumulation to excessively activate the ras/raf/erk/p53-p21 pathway

HIGHLIGHTS

• who: C Lv from the DepartmentMedical University, Shanghai, China have published the Article: Wentilactone A as a novel potential antitumor agent induces apoptosis and G2/M arrest of human lung carcinoma cells, and is mediated by HRas-GTP accumulation to excessively activate the Ras/Raf/ERK/p53-p21 pathway, in the Journal: (JOURNAL)
• what: The authors report here that EN-48-56, known as Wentilactone A (WA), exerts a significantly inhibitory effect on the lung carcinoma cell lines NCI-H460 and NCI-H446 without markedly inhibiting the proliferation of normal HUVECs . . .
  

   

  

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