HIGHLIGHTS
SUMMARY
This study indicated that WFDC21P promoted TNBC cell proliferation in_vitro and in_vitro via the WFDC21P/miR-628/SMAD3 axis. For infection, TNBC cells (1×10 5 cells/well) were treated with 1×10 5 FU lentivirus which overexpressed WFDC21P or miR-628-5p (5′AUGCUGACAUAUUUACUAGAGG-3′). Through the WFDC21P/miR-628-5p/Smad3 axis, WFDC21P significantly promoted cell proliferation and metastasis by negatively regulating miR-628-5p, whereas miR628-5p suppressed TNBC cell proliferation and metastasis by negatively regulating Smad3-related gene_expression. Mo r e ov e r, m i R - 6 2 8 . . .
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