HIGHLIGHTS
SUMMARY
The authors searched for potentially relevant studies through these keywords: PTHrP AND NET/NEN; PTH AND NET/NEN; paraneoplastic hypercalcemia AND NET/NEN; and hypercalcemia AND NET/NEN. The authors furthermore evaluated the primary NEN`s site, grade, staging (with ENETS classification), type of metastasis at diagnosis of paraneoplastic hypercalcemia, NEN and hypercalcemia therapy, and patients` survival from the onset of hypercalcemia. In fact, in the review, the authors observed that, in 27.4% of cases, the combination of multiple treatments (medical therapy for paraneoplastic hypercalcemia and different antineoplastic (both surgical and medical) treatments . . .
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