While reducing doxorubicin-induced cardiotoxicity in triple-negative breast cancer treatment

HIGHLIGHTS

• who: Targeting CAR and colleagues from the DepartmentUniversity of of Medicine, Baltimore, Maryland, USA have published the paper: while reducing doxorubicin-induced cardiotoxicity in triple-negative breast cancer treatment, in the Journal: (JOURNAL) of May/10,/2022
• what: Utilizing a multicellular coculture model incorporating human primary hepatocytes TNBC cells and cardiomyocytes the authors show that CN06 increased CPA/DOX-mediated TNBC cell death via CAR-dependent CYP2B6 induction and subsequent conversion of CPA to its active metabolite 4-hydroxy-CPA while protecting against DOX-induced cardiotoxicity by selectively activating Nrf2antioxidant signaling in cardiomyocytes but not . . .
  

   

  

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