Whole-genome duplication and genome instability in cancer cells: double the trouble

HIGHLIGHTS

  • who: Tsz Yin Lau and Randy Y.C. Poon from the Division of Life Science, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China have published the research work: Whole-Genome Duplication and Genome Instability in Cancer Cells: Double the Trouble, in the Journal: (JOURNAL)

SUMMARY

    Limiting genome duplication to once per cell cycle is critical for maintaining genome stability in human cells. Mechanisms including cell fusion, endomitosis, endoreplication, and cytokinesis failure can generate polyploids through uncoupling of the checkpoint pathways that halt cell cycle progression or induce apoptosis . . .

     

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