Wiskott-aldrich syndrome protein forms nuclear condensates and regulates alternative splicing

HIGHLIGHTS

• who: Baolei Yuan from the King Abdullah University of USA have published the Article: Wiskott-Aldrich syndrome protein forms nuclear condensates and regulates alternative splicing, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: The authors demonstrate that WASP is a phase-separated protein that can directly participate in the process of RNA_splicing during transcription through physical association with target genes and components of the gene-body condensates (e_g, active Pol II, SFs, and nascent RNA) (Supplementary Fig S12).
• how: A similar observation was made in mutant B-cell lines (Supplementary Fig S5f). As . . .
  

   

  

  If you want to have access to all the content you need to log in!

  Thanks :)

  Username or Email

  Password

  Remember me

  Lost your password?

  If you don't have an account, you can create one here.