Withanolide e sensitizes renal carcinoma cells to trail-induced apoptosis by increasing cflip degradation

HIGHLIGHTS

• who: C J Henrich from the Molecular Targets LaboratoryClark University, Worcester, MA, USA have published the paper: Withanolide E sensitizes renal carcinoma cells to TRAIL-induced apoptosis by increasing cFLIP degradation, in the Journal: (JOURNAL)

SUMMARY

Withanolide E had the least growth inhibitory effect as a single agent (5.7% reduction in cell number at 10 μM as compared with 10.9% for 4β-hydroxy withanolide E, 21.9% for withanolide S, 39.5% for dehydrowithanolide E, and 44.0% for withaferin A). The increased apparent potency of withanolide E +TRAIL in longer . . .

 



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